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The Gut-Microbiome-Brain Axis

In this episode, we discussed how the collection of microorganisms that line the gut, the microbiome, is implicated in mental health and neurological disorders.

What is the gut microbiome?

“Defining the human microbiome”

“Introduction to the human gut microbiota”

An excellent review on the involvement of the gut microbiome in brain disorders:

"The gut microbiome and mental health: advances in research and emerging priorities" Shoubridge et al. (2022)

How is the gut microbiome implicated in brain disorders?

The gut microbiome affects autism-like behaviour in mice (Li et al., 2020):

Changes to the gut microbiome causes anhedonia-like behaviour in mice via the vagus nerve Wang et al. (2020):

Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats Crumeyrolle-Arias et al. (2014):

Neuroprotective effects of fecal transplant in a mouse model of Parkinson's disease Sun et al. (2018):

Posters referred to:

“Studies on Hippocampal Histoarchitecture and Neurochemistry in Psychologically Stressed Rats Given Gut Microbiome Supplementation”

Afoluwajuwonlo G. Obaoye, FENS poster

"Social isolation in adolescence: changes in the gut microbiota composition and in the hippocampal inflammation"

Nicola Lopizzo, FENS poster

"Dissecting the contribution of host genetics and the microbiome in complex behaviors"

Sean W. Dooling, FENS poster

An interesting TED talk on the topic:


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